Research Introduction

transdisciplinary microbiomics 2022.pdf
Tumor microbiota metastasizes with tumor cells and influences tumor progression and drug sensitivity. We published a review article in Gut on the necessity of a transdisciplinary approach to promote the field of tumor microbiomics.

F. nucleatum in CRC liver metastasis 2024.pdf
We discovered that the presence of Fusobacterium nucleatum in colorectal cancer liver metastases correlates with elevated serum CRP levels, a low number of CD8-positive cytotoxic T lymphocytes and FOXP3 regulatory T cells in the tumor microenvironment, and a tendency for metastasis beyond the liver upon recurrence.

pks-carrying E. coli in CRC liver metastasis 2024.pdf
We found that when pks-carrying E. coli is present in colorectal cancer liver metastases, serum CRP levels are lower, CD4-positive T lymphocytes and CD163-positive macrophages are less abundant in the tumor microenvironment, and the cancer tends not to metastasize beyond the liver upon recurrence.

Inverted urothelial carcinoma 2023.pdf
We discovered that inverted papilloma of the bladder frequently harbor the HRAS Q61R mutation, and immunostaining for RAS Q61R revealed. the neoplastic nature of the overlying morphologically normal urothelial cells.

Lung choriocarcinoma 2022.pdf
A sequencing analysis of an autopsied case demonstrated that lung choriocarcinoma and adenocarcinoma originated from a common clone harboring an EGFR mutation. This study was featured on the cover of the Journal of Thoracic Oncology.
 

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Under Preparation